Endocrine Abstracts

Introduction: Hypoparathyroidism (HypoPT) is a rare endocrine disease which is characterized by hypocalcaemia and undetectable or inappropriately low serum parathyroid hormone (PTH). Post-surgical HypoPT (PS-HypoPT) is the most common cause, caused by accidental parathyroid removal/injury during neck surgery. From a neuropsychological standpoint, patients with PS-HypoPT present cognitive and neuropsychological symptoms: the more plausible pathophysiological mechanism resides i...

Obesity is a multifactorial disease in which environmental conditions and genetic factors play an important pathogenic role [1]. Interestingly, some of these obesogenic environmental and genetic conditions are shared with neurodegenerative diseases (NDD). The common biological mechanisms involved in obesity and NDD are insulin resistance, pro-inflammatory cytokines, and oxidative damage, in turn leading to cognitive dysfunction or cell death. In this aspect, a poly-pharmacolog...

Introduction: Hypoparathyroidism (HypoPT) is a rare endocrine disease which is characterized by hypocalcaemia and undetectable or inappropriately low serum parathyroid hormone (PTH). Post-surgical HypoPT (PS-HypoPT) is the most common cause, caused by accidental parathyroid removal/injury during neck surgery. Conventional therapy with calcium and vitamin D analogues does not restore calcium homeostasis and patients with chronic PS-HypoPT complain with several complications. Fr...